FACT sets a barrier for cell fate reprogramming in C. elegans and Human

Ena Kolundzic, Andreas Ofenbauer, Bora Uyar, Anne Sommermeier, Stefanie Seelk, Mei He, Gülkiz Baytek, Altuna Akalin, Sebastian Diecke, Scott Allen Lacadie, Baris Tursun.

bioRxiv 2017, doi:

Application of RNAi and heat-shock-induced transcription factor expression to reprogram germ cells to neurons in C. elegans.

Ena Kolundžić, Stefanie Seelk, Baris Tursun

JoVE 2017 (in press)

Neuronal Inhibition Of The Autophagy Nucleation Complex Extends Lifespan In Post-Reproductive C. elegans.

Thomas Wilhelm, Jonathan Byrne, Rebeca Medina, Ena Kolundžić, Johannes Geisinger, Martina Hajduskova, Baris Tursun and Holger Richly. 

Genes and Development 2017, September 7, doi: 10.1101/gad.301648.117.

Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons.

Seelk S, Adrian-Kalchhauser I, Hargitai B, Hajduskova M, Gutnik S, Tursun B#, Ciosk R#.

Elife. 2016 Sep 7;5. pii: e15477. doi: 10.7554/eLife.15477.

PMID: 27602485 (#co-correspondence)

A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large.

Waaijers S, Muñoz J, Berends C, Ramalho JJ, Goerdayal SS, Low TY, Zoumaro-Djayoon AD, Hoffmann M, Koorman T, Tas RP, Harterink M, Seelk S, Kerver J, Hoogenraad CC, Bossinger O, Tursun B#, van den Heuvel S, Heck AJ, Boxem M#.

BMC Biol. 2016 Aug 9;14:66. doi: 10.1186/s12915-016-0286-x.

PMID: 27506200 (#co-correspondence)

Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1.

Cochella L*, Tursun B*, Hsieh YW, Galindo S, Johnston RJ, Chuang CF, Hobert O.

Genes Dev. 2014 Jan 1;28(1):34-43. doi: 10.1101/gad.233643.113. Epub 2013 Dec 20.

PMID: 24361693 (*co-first)

Removal of Polycomb repressive complex 2 makes C. elegans germ cells susceptible to direct conversion into specific somatic cell types.

Patel T*, Tursun B*, Rahe DP, Hobert O.

Cell Rep. 2012 Nov 29;2(5):1178-86. doi: 10.1016/j.celrep.2012.09.020. Epub 2012 Oct 25.

PMID: 23103163 (*co-first)

Cellular reprogramming processes in Drosophila and C. elegans.

Tursun B.

Curr Opin Genet Dev. 2012 Oct;22(5):475-84. doi: 10.1016/j.gde.2012.09.005. Epub 2012 Oct 11. Review.

PMID: 23063246

Direct conversion of C. elegans germ cells into specific neuron types.

Tursun B#, Patel T, Kratsios P, Hobert O. (#co-corresponding)

Science. 2011 Jan 21;331(6015):304-8. doi: 10.1126/science.1199082. Epub 2010 Dec 9.

PMID: 21148348 

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The Groucho ortholog UNC-37 interacts with the short Groucho-like protein LSY-22 to control developmental decisions in C. elegans.

Flowers EB, Poole RJ, Tursun B, Bashllari E, Pe'er I, Hobert O.

Development. 2010 Jun;137(11):1799-805. doi: 10.1242/dev.046219. Epub 2010 Apr 28.

PMID: 20431118

Neuron-type specific regulation of a 3'UTR through redundant and combinatorially acting cis-regulatory elements.

Didiano D, Cochella L, Tursun B, Hobert O.

RNA. 2010 Feb;16(2):349-63. doi: 10.1261/rna.1931510. Epub 2009 Dec 29.

PMID: 20040592

The C. elegans Tailless/TLX transcription factor nhr-67 controls neuronal identity and left/right asymmetric fate diversification.

Sarin S, Antonio C, Tursun B, Hobert O.

Development. 2009 Sep;136(17):2933-44. doi: 10.1242/dev.040204. Epub 2009 Jul 29.

PMID: 19641012

A toolkit and robust pipeline for the generation of fosmid-based reporter genes in C. elegans.

Tursun B*#, Cochella L*, Carrera I, Hobert O.# (#co-corresponding)

PLoS One. 2009;4(3):e4625. doi: 10.1371/journal.pone.0004625. Epub 2009 Mar 4.

PMID: 19259264

Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer.

Johnsen SA, Güngör C, Prenzel T, Riethdorf S, Riethdorf L, Taniguchi-Ishigaki N, Rau T, Tursun B, Furlow JD, Sauter G, Scheffner M, Pantel K, Gannon F, Bach I.

Cancer Res. 2009 Jan 1;69(1):128-36. doi: 10.1158/0008-5472.CAN-08-1630.

PMID: 19117995

Proteasomal selection of multiprotein complexes recruited by LIM homeodomain transcription factors.

Güngör C, Taniguchi-Ishigaki N, Ma H, Drung A, Tursun B, Ostendorff HP, Bossenz M, Becker CG, Becker T, Bach I.

Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15000-5. Epub 2007 Sep 11. Erratum in: Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17239.

PMID: 17848518

Dynamic expression of LIM cofactors in the developing mouse neural tube.

Ostendorff HP*, Tursun B*, Cornils K, Schlüter A, Drung A, Güngör C, Bach I.

Dev Dyn. 2006 Mar;235(3):786-91. (*co-first)

PMID: 16395690

The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones.

Tursun B, Schlüter A, Peters MA, Viehweger B, Ostendorff HP, Soosairajah J, Drung A, Bossenz M, Johnsen SA, Schweizer M, Bernard O, Bach I.

Genes Dev. 2005 Oct 1;19(19):2307-19. Erratum in: Genes Dev. 2005 Nov 1;19(21):2643.

PMID: 16204183

Mitochondrial signal peptidases of yeast: the rhomboid peptidase Pcp1 and its substrate cytochrome C peroxidase.

Michaelis G, Esser K, Tursun B, Stohn JP, Hanson S, Pratje E.

Gene. 2005 Jul 18;354:58-63.

PMID: 15979251

Comparing protein stabilities during zebrafish embryogenesis.

Becker T, Bossenz M, Tursun B, Schlüter A, Peters MA, Becker CG, Ostendorff HP, Bach I.

Methods Cell Sci. 2003;25(1-2):85-9.

PMID: 14739592

A novel two-step mechanism for removal of a mitochondrial signal sequence involves the mAAA complex and the putative rhomboid protease Pcp1.

Esser K, Tursun B, Ingenhoven M, Michaelis G, Pratje E.

J Mol Biol. 2002 Nov 8;323(5):835-43.

PMID: 12417197